Every seat in the house has gone and home coach Dai Flanagan is hoping the terraces are full to the brim to give his side the chance to make amends for their Boxing Day collapse at Cardiff Arms Park.
It will be the 100th appearance for the Dragons for Wales back row forward Aaron Wainwright and he will pack down at No 8 in a side that shows eight changes from the one beaten 55-21 last week.
Aaron Wainwright reaches 100 games for Dragons
At the other end of the experience scale, centre Harri Ackerman, a try scorer for Newport in their Indigo Premiership win at Pontypool Park last weekend, earns his first start for the Dragons alongside Aneurin Owen. Ackerman turned 19 on 21 December.
Leon Brown appears among the home replacements, as does Wales U20 skipper Ryan Woodman. There are five international players in the starting XV and three more on the bench.
The Scarlets, however, will travel fully loaded with Wales outside half Sam Costelow set to make his return after recovering from two injuries sustained in the final World Cup game in France. He fits into a side that boasts 14 internationals, with only lock Morgan Jones being uncapped to date.
They even have two British & Irish Lions on the bench in Wyn Jones and Jonathan Davies, as well as another Wales cap in Kieran Hardy. After suffering a home defeat to Ospreys on Boxing Day, head coach Dwayne Peel will be seeking a major reaction from his side.
Dragons: Cai Evans; Jared Rosser, Aneurin Owen, Harri Ackerman, Ewan Rosser; Will Reed, Rhodri Williams (captain); Rodrigo Martinez, James Benjamin, Lloyd Fairbrother, Sean Lonsdale, George Nott, Dan Lydiate, Harri Keddie, Aaron Wainwright
Reps: Brodie Coghlan, Rhodri Jones, Leon Brown, Joe Davies, Ryan Woodman, Ollie Griffiths, Dane Blacker, Corey BaldwinScarlets: Ioan Lloyd; Tom Rogers, Joe Roberts, Johnny Williams, Steff Evans; Sam Costelow, Gareth Davies; Kemsley Mathias, Ryan Elias, Sam Wainwright, Alex Craig, Morgan Jones, Sam Lousi, Josh Macleod (captain), Vaea Fifita
Reps: Shaun Evans, Wyn Jones, Joe Jones, Jac Price, Ben Williams, Kieran Hardy, Jonathan Davies, Ioan Nicholas
The Ospreys have taken their clash with Cardiff Rugby to the Brewery Field at Bridgend (kick-off 3.00pm) and the big prize for whoever wins is the chance to jump into the play-off places in the Top 8.
Ospreys will meet Cardiff Rugby in Bridgend at the Brewery Field
Lock Adam Beard will captain the side for the third game in succession and centre Owen Watkin will bring up his century of appearances for the region. There are five changes from the side that won 25-11 at Parc Y Scarlets on Boxing Day.
Cardiff have Ellis Jenkins back after suspension to fit into the back row alongside Lopeti Timani and Jim Botham.
Ospreys: Jack Walsh; Iestyn Hopkins, George North, Owen Watkin, Keelan Giles; Owen Williams, Luke Davies; Gareth Thomas, Sam Parry, Tom Botha, James Fender, Adam Beard (captain), James Ratti, Harri Deaves, Morgan Morse
Reps: Dewi Lake, Garyn Phillips, Rhys Henry, Lewis Jones, Tristan Davies, Cameron Jones, Dan Edwards, Luke MorganCardiff Rugby: Cam Winnett; Owen Lane, Rey Lee-Lo, Willis Halaholo, Mason Grady; Tinus de Beer, Tomos Williams; Corey Domachowski, Liam Belcher, Keiron Assiratti, Seb Davies, Teddy Williams, James Botham, Ellis Jenkins, Lopeti Timani
Reps: Efan Daniel, Rhys Carre, Rhys Litterick, Rory Thornton, Josh Turnbull, Mackenzie Martin, Ellis Bevan, Jacob Beetham
Owen Watkin reaches a century of games for the Ospreys
