Wales got off to a flyer when scrum-half Orson James raced over the line for a converted score inside a minute.
However, France hit back two minutes later when Hoani Bosmorin scored in the corner and Hugo Reus’s conversion made it a level game.
Gabin Rocher was next to score for France on home soil, the game’s third try in six minutes, after winning the foot race to scrum-half Lucas Zamora’s box kick.
France’s third score came from flanker Andy Timo after a quick tap and a fourth came when outside centre Maxence Biasotto sauntered in after 15 minutes.
Wales retaliated through captain Harri Ackerman to reduce the gap to 12 but a fortuitous bounce of the ball allowed prop Lino Julien to score his side’s fifth.
Full-back Maxime Tetlow set up Bosmorin for the second time in the match as France notched a sixth score before Rocher secured his second following some neat footballing skills to end a pulsating first half at 45-14.
The eighth try of the game came when Emilien Trezieres sold a dummy and crashed over to take France past the 50-point mark before Wales scored another when James’ support play earned him a second 12 minutes into the second period.
France finished with a flourish as Rocher and Bosmorin completed their hat-tricks to provide a fitting end to a convincing display.
