Bristol Bears v Wasps on Sunday will be the first game to be televised in round six first plays third as the Bears go for their sixth straight win in the competition.
Wales internationals Manon Johnes, Alisha Butchers, Elinor Snowsill, Kayleigh Powell, Courtney Keight and Keira Bevan all return to the Bears, with compatriot Talia John also named among the replacements.
Wasps have fly half Flo Williams, who made her Wales debut against Canada, and Gemma Rowlands at full-back among their starters.
Sale Sharks face the daunting prospect of hosting defending champions, Harlequins at The CorpAcq Stadium.
Lisa Neumann on back on the wing for the home side while Teleri Wyn Davis starts in the second row start for the Sharks with Molly Kelly, Gwenllian Pyrs and Jess Roberts on the replacements bench.
DMP welcome Worcester Warriors to the Darlington Arena where Carys Phillips and Alex Callender return from Wales duty to pack down for Worcester with Ffion Lewis starting at scrum half.
There is a strong Welsh presence in the Gloucester-Hartpury side taking on Saracens where recently engaged centre Hannah Jones returns from Welsh duty to join LLeucu George at fly half while in the forwards Cara Hope and Cerys Hale are in the front row, Gwen Crabb is in the second row and Bethan Lewis starts in the back row.
Donna Rose shores up the scrum for Saracens at tighthead prop while Kat Evans and Georgia Evans both start from the bench.
