Davies will line-up at half-back alongside Dan Biggar in the only change in the backline. Hadleigh Parkes and Nick Tompkins partner in the midfield with Josh Adams, George North and Leigh Halfpenny comprising the back-three.
Moriarty comes into the side at blindside flanker to set-up an all British & Irish Lions back-row. Jake Ball and captain Alun Wyn Jones continue in the second-row with Wyn Jones, Ken Owens and Dillon Lewis named in the front-row.
“Gareth was unavailable round one and came off the bench last time out so he is full of energy and we are looking forward to him bringing his game on Saturday,” said Wales head coach Wayne Pivac.
“Ross has impressed off the bench so far and brought a lot of energy and communication as well so he deserves an opportunity to start.
“We have changed around the second-rows on the bench, we are looking at creating competition there and Will has trained well and we are looking forward to seeing him out on that stage.
“We want to build on what we have done so far and are looking to be more accurate with what we do and improve on that aspect.
“Saturday is going to be a packed Principality Stadium, we know the atmosphere will be electric and it is set for a big day in Cardiff.”
On the bench Ryan Elias, Rob Evans and Leon Brown provide the front-row cover with uncapped second-row Will Rowlands and Aaron Wainwright completing the forward contingent. Tomos Williams, Jarrod Evans and Johnny McNicholl provide the backline cover.
WALES TEAM TO PLAY FRANCE (Saturday February 22 KO 16.45 BBC & S4C)
15. Leigh Halfpenny (87 Caps)
14. George North (93 Caps)
13. Nick Tompkins (2 Caps)
12. Hadleigh Parkes (27 Caps)
11. Josh Adams (23 Caps)
10. Dan Biggar (81 Caps)
9. Gareth Davies (52 Caps)
1. Wyn Jones (24 Caps)
2. Ken Owens (75 Caps)
3. Dillon Lewis (24 Caps)
4. Jake Ball (44 Caps)
5. Alun Wyn Jones (C) (136 Caps)
6. Ross Moriarty (43 Caps)
7. Justin Tipuric (74 Caps)
8. Taulupe Faletau (74 Caps)
Replacements:
16. Ryan Elias (11 Caps)
17. Rob Evans (37 Caps)
18. Leon Brown (8 Caps)
19. Will Rowlands (*Uncapped)
20. Aaron Wainwright (20 Caps)
21. Tomos Williams (18 Caps)
22. Jarrod Evans (5 Caps)
23. Johnny McNicholl (2 Caps)
