New signing Ryan Lamb will pull on a Scarlets jersey for the first time, while the Blues will have Dan Fish at No 10 as they go in search of their second win in the competition this season. Their only other success came in their 40-31 home triumph over Dragons A, while the Scarlets are guaranteed to finish as the highest placed Welsh region.
The 33-year-old Lamb has vast experience in the English Premiership and more recently played for La Rochelle in the Top 14. Lamb is one of three changes from the side that thumped Munster 46-28 at Carmarthen Park last Saturday.
Macauley Cook returns to captain the Blues side, while Kirby Myhill is also included at hooker. There are a total of 11 changes from the side that went down to Connacht Eagles last week, with academy centres Max Llewellyn and Ben Thomas combining in midfield.
The Dragons meet the Ospreys at Ystrad Mynach on Satruday, 5 October (3.00pm kick-off) in the final game of the campaign.
Cardiff Blues A: Ioan Davies; Sam Jones, Max Llewellyn, Ben Thomas, Mason Grady; Dan Fish, Jamie Hill; Lewis Francis, Kirby Myhill, Ben Warren, Macauley Cook (captain), Teddy Williams, Aled Ward, James Botham, Tim Grey
Reps: Cameron Lewis, Chris Phillips, Ollie Drake, James Ratti, Gwilym Bradley, Zach Bartlett, Rhys Davies, Dafydd Smith
Scarlets A: Tom Prydie; Tomi Lewis, Tom Rogers, Osian Knott, Morgan Williams; Ryan Lamb, Jonathan Evans; Steffan Thomas, Dafydd Hughes, Javan Sebastian, Jac Price, Morgan Jones, Danny Drake, Jac Morgan (captain), Lewys Millin
Reps: Dylan Evans, Shaun Evans, Simon Gardiner, Chris Long, Lewis Ellis-Jones, Daf Land, Ioan Hughes, Ryan Davies
Dragons A: David Richards; Ewan Rosser, Tom Hoppe, Aneurin Owen, James McCarthy ; Arwel Robson, Dafydd Buckland; Jack Cosgrove, Will Griffiths, Luke Yendle, James Sheekey, Ben Carter, Benjamin Fry, Ben Roach (captain), Garin Price
Reps: Brodie Coghlan , Dylan Bartlett , Christian Coleman, Max Ayling, Benji Hoppe, Dan Babos, Carwyn Penny, Ollie Lewis, Joe Goodchild, Morgan Richards
Ospreys Development XV: Caine Woolerton; George Gasson, Callum Carson, Kieran Williams, Dewi Cross; Josh Thomas, Reuben Morgan-Williams; Rhys Davies, Ifan Phillips, Jordan Pritchard, Rhys Thomas, Jay Williams (captain), Travis Huntley, Morgan Morris, Guido Volpi
Reps: Dewi Lake, Jordan Walters, Ben Warren, Iwan Shenton, Joe Grabham, Harri Morgan, Cameron Lewis, Phil Jones
