Neath, who are bottom of the table will look to bounce back after a disappointing start to the season after gaining only two bonus points so far and without a win.
The last time Pontypridd played Neath in the league was on the 17thJanuary 2015. Ponty travelled to the Gnoll and came away with a narrow win of 20-18.
Pontypridd played Neath, also in the league at home over a year ago on Saturday 13th September 2014. Ponty were again victorious with a score of 38-7.
This weekend, Neath will hope that their fortunes pick up and Pontypridd will want to get back to winning ways, making for an intriguing top versus bottom Premiership clash.
Pontypridd make no fewer than 12 changes, in personnel or positional, from the team that started in the defeat at Cross Keys.
Prop Keiron Jenkins has withdrawn with a shoulder strain, with hooker Huw Dowden redefining himself by taking over the tight head position. Dan Godfrey reverts from the second to the back row, with youngster Hemi Barnes moving the other way to start at lock.
Pontypridd: 15 Geraint Walsh 14 Alex Webber 13 Gavin Dacey 12.Dafydd Lockyer (Capt) 11 Chris Clayton 10 Ceri Sweeney 9 Joel Raikes; 1 Corey Domachowski 2 Ashleigh James 3 Huw Dowden 4 Hemi Barnes 5.Seb Davies 6 Jake Thomas 7 Wayne O’Connor 8 Dan Godfrey.
Subs: 16 Lloyd Williams 17 Lewis K Williams 18 Gary Williams 19.Bradley Thyer 20 Rhys Shellard 21 Shaun O’Rourke 22.Keiron Assiratti 23.Chris Phillips.
