Former European finalists Biarritz will travel to the Liberty Stadium on Saturday 12 November, a week before the Ospreys head to Italy to line-up against Benetton Treviso.
Rounds 3 and 4 see back to back games against Saracens, the first being held at Wembley Stadium.
Following their trip to France, the Blues welcome London Irish to the Welsh capital before back to back games against Edinburgh in December.
The Scarlets will play last season’s runners-up Northampton Saints in their first away trip before Munster travel to the Parc y Scarlets on December 10.
Ospreys Heineken Cup fixtures:
12/11/11 (15:40) Ospreys v  Biarritz Olympique Pays Basque – S4C
19/11/11 (14:30) Benetton Treviso v  Ospreys – Sky Italia
10/12/11 (18:00) Saracens v  Ospreys – Sky Sports
16/12/11 (20:00) Ospreys v  Saracens – Sky Sports
13/14/15 Jan Ospreys v  Benetton Treviso
20/21/22 Jan Biarritz Olympique Pays Basque v  Ospreys
Blues Heineken Cup fixtures:
11/11/11( 21:00) Racing Métro 92 v  Cardiff Blues – Canal +
18/11/11 (20:00) Cardiff Blues v  London Irish – S4C
9/12/11 (20:00) Cardiff Blues v  Edinburgh – S4C
16/12/11 (20:00) Edinburgh v  Cardiff Blues – S4C
13/14/15 Jan London Irish v  Cardiff Blues
20/21/22 Jan Cardiff Blues v  Racing Métro 92
Scarlets Heineken Cup fixtures:
12/11/11(15:00) Scarlets v  Castres Olympique
18/11/11 (20:00) Northampton Saints v  Scarlets -Sky Sports
10/12/11 (15:40) Scarlets v  Munster – Sky Sports
18/12/11 (12:45) Munster v  Scarlets – Sky Sports
13/14/15 Jan Scarlets v  Northampton Saints
20/21/22 Jan Castres Olympique v  Scarlets
