There will be scrapping for points at the other end of the table as Pontypool take on Llanharan and Ebbw Vale host Llandovery at Eugene Cross Park.
Both Pontypridd and Bridgend won in midweek and they now battle it out at Sardis Road in a match that will see the Celtic Warrior theme in both camps.
Bottom club Caerphilly look for a first win as they welcome Cross Keys to Virginia Park and Bedwas hope for a bit of luck as they take on Newbridge at the Welfare Ground.
Former Swansea centre Kevin Hopkins will be hoping to coach his new club Aberavon to victory over the All Whites at the Talbot Athletic Ground.
