James Botham, Kieran Hardy and Johnny Williams will all make their debuts and are part of the 13 changes head coach Wayne Pivac has made to the side that lost to Ireland.
Fly-half Callum Sheedy and wing Louis Rees-Zammit will make their first Test starts while Sheedy’s Bristol Bears team-mate loan Lloyd is also poised for a full debut off the bench.
“There is so much potential and quality still in the team. It’s about enjoying it and letting the boys express themselves in the right way”, said experienced openside flanker Tipuric.
“It’s unbelievable the amount of quality out there.
“The players coming in have been tearing it up all year with their clubs. It’s just about us all gelling as a team. That’s going to be the biggest thing.
“You see the boys in training getting excited and there is a lot of energy. Some of the training has been excellent and there has been a lot of buzz amongst it all.
“It’s just about keeping them calm and doing it in the right situations.
“No one likes losing and it’s tough when you do lose. We have an opportunity on the weekend where there are a few new fresh faces to put their hand up for the England game.”
Tipuric is also wary of the threat Georgia will pose.
Despite a comfortable win over Los Lelos in the pool stages of the 2019 Rugby World Cup, Wales were only 13-6 victors against the giant Eastern Europeans in Cardiff in 2017.
“If Georgia get confident and they get a few driving mauls going, they’re a different animal,” said Tipuric.
“We need to make sure we start well, attack them with our set-piece, and not let them do all the attacking.
“We can’t just expect a win is going to come or someone will just make something happen. We’ve got to go out there and start with a bang.
“We know it’s going to be hard graft up front, especially against such a big pack like Georgia.
“We know it’s going to be tough and physical and probably lots of set-pieces will be involved.
“To get the backs in the game we need to front up and perform.”