Wales, who currently top their pool with three wins from three games, have already secured a quarter-final berth and take on Uruguay in Kumamoto to close out their pool campaign.
Tipuric will line-up alongside Aaron Shingler and Aaron Wainwright in a new look back row.
Ospreys duo Bradley Davies and Adam Beard will pack down in the second row with Nicky Smith, Ryan Elias and Dillon Lewis named in the front row.
Aled Davies and Rhys Patchell will partner at half-back with Hadleigh Parkes and Owen Watkin comprising the midfield. Hallam Amos and Leigh Halfpenny come into the back-three alongside Josh Adams who claimed a World Cup hat-trick against Fiji in Wales’ last outing.
On the bench Elliot Dee, Rhys Carre and Wyn Jones provide the front row cover with Jake Ball, Ross Moriarty and James Davies also amongst the replacements. Tomos Williams and Gareth Davies are named as the backline cover.
WALES TEAM TO PLAY URUGUAY (SUNDAY OCTOBER 13 KO 17.15 Japan):
15. Leigh Halfpenny (Scarlets) (83 Caps)
14. Josh Adams (Cardiff Blues) (17 Caps)
13. Owen Watkin (Ospreys) (18 Caps)
12. Hadleigh Parkes (Scarlets) (21 Caps)
11. Hallam Amos (Cardiff Blues) (20 Caps)
10. Rhys Patchell (Scarlets) (16 Caps)
9. Aled Davies (Ospreys) (19 Caps):
1. Nicky Smith (Ospreys) (33 Caps)
2. Ryan Elias (Scarlets) (8 Caps)
3. Dillon Lewis (Cardiff Blues) (18 Caps)
4. Bradley Davies (Ospreys) (65 Caps)
5. Adam Beard (Ospreys) (16 Caps)
6. Aaron Shingler (Scarlets) (23 Caps)
7. Justin Tipuric (Ospreys) (68 Caps) (Capt)
8. Aaron Wainwright (Dragons) (15 Caps)
16. Elliot Dee (Dragons) (25 Caps)
17. Rhys Carre (Saracens) (2 Caps)
18. Wyn Jones (Scarlets) (18 Caps)
19. Jake Ball (Scarlets) (39 Caps)
20. Ross Moriarty (Dragons) (37 Caps)
21. James Davies (Scarlets) (6 Caps)
22. Tomos Williams (Cardiff Blues) (12 Caps)
23. Gareth Davies (Scarlets) (47 Caps)