Warren Gatland’s hosts have won their last eight games and are aiming for what would be their first November clean sweep when they meet the Springboks.
Wales’ last three games with South Africa have all ended in victory, but Rassie Erasmus’ men have designs on breaking that run.
“Wales have a formidable squad and their current run of eight unbeaten Tests is proof and also an indication of their good form at the moment,” said South Africa head coach Erasmus.
“As I’ve said before, we know Saturday’s Test is going to be our most difficult match of the tour. “Wales defeated us in Washington in June and have now won the last three games against us.
“They are a well-balanced and strong side with a great home record so our boys will be in for a massive contest on Saturday.
“We will be desperate to win and to end the tour on a high would be fantastic for the experience and growth of this squad.”
The game in Cardiff will be the first time this season the Springboks run out with an unchanged line-up, but there is one change among the replacements from the team which beat Scotland.
Eben Etzebeth is set to provide impact off the bench after the experienced lock recovered from a calf problem. He comes into the 23-man squad in place of Lood de Jager.
Duane Vermeulen, Pieter-Steph du Toit and captain Siya Kolisi form a first-class South African back-row trio.
Franco Mostert and RG Snyman start at lock while Frans Malherbe, Malcolm Marx and Steven Kitshoff will pack
down in the front row.
Jesse Kriel will play in his 40th Test match for the Springboks and he lines up next to Damian de Allende at centre.
Handre Pollard and Embrose Papier are the half backs and the back three consists of full-back Willie le Roux and speedsters Sbu Nkosi and Aphiwe Dyantyi.
South Africa lost by a point to England in their first game of their northern hemisphere tour, but have responded with victories over France and Scotland.
South Africa: Le Roux; Nkosi, Kriel, De Allende, Dyantyi; Pollard, Papier; Kitshoff, Marx, Malherbe, Snyman, Mostert, Kolisi (capt), P Du Toit, Vermeulen
Replacements: Mbonambi, T Du Toit, Koch, Etzebeth, Louw, Van Zyl, Jantjies, Kolbe
