It means North will miss this summer’s British & Lions tour to South Africa.
North was in stunning form as he helped Wales to win the Six Nations last month and his move from wing to centre at Test level has seen him add another layer to his game.
The 29-year-old’s fine Six Nations meant he was firmly in the frame to make Warren Gatland’s Lions squad for the Test series with South Africa when it is confirmed on May 6.
It would have been North’s third Lions tour, but he has been cruelly struck down by injury.
“Sport can be cruel. We all know the risks when we take the field,” North said.
“Unfortunately, I ruptured my ACL on Saturday and will need surgery next week. Heartbroken is an understatement.”
